Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
From Wikipedia, the free encyclopedia
In enzymology, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) is an enzyme that catalyzes the chemical reaction
| glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | |||||||||
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| Identifiers | |||||||||
| EC no. | 1.2.1.12 | ||||||||
| CAS no. | 9001-50-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The three substrates of this enzyme are D-glyceraldehyde-3-phosphate, phosphate (Pi), and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 1,3-bisphosphoglyceric acid, reduced NADH, and a proton.[1] This enzyme participates in glycolysis and gluconeogenesis.[2][3][4]
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate, phosphoglyceraldehyde dehydrogenase, 3-phosphoglyceraldehyde dehydrogenase, NAD+-dependent glyceraldehyde phosphate dehydrogenase, glyceraldehyde phosphate dehydrogenase (NAD+), glyceraldehyde-3-phosphate dehydrogenase (NAD+), NADH-glyceraldehyde phosphate dehydrogenase, and glyceraldehyde-3-P-dehydrogenase.
See also
- Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) which catalyses the same reaction using nicotinamide adenine dinucleotide phosphate as its cofactor
