Glycerol-3-phosphate dehydrogenase (NAD+)

In enzymology, a glycerol-3-phosphate dehydrogenase (NAD⁺) (EC 1.1.1.8) is an enzyme that catalyzes the chemical reaction

sn glycerol 3-phosphate

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

dihydroxyacetone phosphate

+ NADH

 

EC no.1.1.1.8

CAS no.9075-65-4

BRENDAenzyme data

ExPASyNiceZyme view

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Glycerol-3-phosphate dehydrogenase (NAD+)
Identifiers
EC no.	1.1.1.8
CAS no.	9075-65-4
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

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The two substrates of this enzyme are sn-glycerol 3-phosphate and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are dihydroxyacetone phosphate, the reduced cofactor NADH, and a proton.^[1]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NAD⁺ 2-oxidoreductase. Other names in common use include alpha-glycerol phosphate dehydrogenase (NAD⁺), alpha-glycerophosphate dehydrogenase (NAD⁺), glycerol 1-phosphate dehydrogenase, glycerol phosphate dehydrogenase (NAD⁺), glycerophosphate dehydrogenase (NAD⁺), hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase, NAD⁺-alpha-glycerophosphate dehydrogenase, NAD⁺-dependent glycerol phosphate dehydrogenase, NAD⁺-dependent glycerol-3-phosphate dehydrogenase, NAD⁺-L-glycerol-3-phosphate dehydrogenase, NAD⁺-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, and glycerol-3-phosphate dehydrogenase (NAD⁺). This enzyme participates in glycerophospholipid metabolism.