Glycochenodeoxycholic acid

Glycochenodeoxycholic acid, also abbreviated as GCDCA,^[1] is a bile salt formed in the liver from chenodeoxycholic acid and glycine, usually found as the sodium salt.^[2][3] It acts as a detergent to solubilize fats for absorption.^{[citation needed]}

Quick facts Names, Identifiers ...

Glycochenodeoxycholic acid

Names
IUPAC name N-(3α,7α-Dihydroxy-5β-cholan-24-oyl)glycine
Systematic IUPAC name {(4R)-4-[(1R,3aS,3bR,4R,5aS,7R,9aS,9bS,11aR)-4,7-Dihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanamido}acetic acid
Identifiers
CAS Number	640-79-9 Y
3D model (JSmol)	Interactive image
ChemSpider	12027 N
IUPHAR/BPS	4545
PubChem CID	12544
UNII	451ZNJ667Y Y
CompTox Dashboard (EPA)	DTXSID301020165
InChI InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 N Key: GHCZAUBVMUEKKP-GYPHWSFCSA-N N
SMILES C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
Properties
Chemical formula	C26H43NO5
Molar mass	449.62 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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Positive associations were observed between prediagnostic plasma levels of seven different conjugated bile acid metabolites, including glycochenodeoxycholic acid, and colon cancer risk.^[4] These findings support experimental data suggesting that a high bile acid load promotes colon cancer.^[4][5]