Glycoside-pentoside-hexuronide:cation symporter family
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| Identifiers | |
|---|---|
| Symbol | ? |
| InterPro | IPR001927 |
| TCDB | 2.A.2 |
| OPM superfamily | 15 |
| OPM protein | 4m64 |
The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family is part of the major facilitator superfamily and catalyzes uptake of sugars (mostly, but not exclusively, glycosides) in symport with a monovalent cation (H+ or Na+).[1] The various members of the family have been reported to use Na+, H+ or Li, Na+ or Li+, or all three cations as the symported cation.
Proteins of the GHP family are generally about 500 amino acids in length, although the Gram-positive bacterial lactose permeases are larger, due to a C-terminal hydrophilic domain that is involved in regulation by the phosphotransferase system. All of these proteins possess twelve putative transmembrane α-helical spanners.