Empagliflozin/linagliptin
Pharmaceutical drug
From Wikipedia, the free encyclopedia
Empagliflozin/linagliptin, sold under the brand name Glyxambi, is a fixed-dose combination anti-diabetic medication used to treat type 2 diabetes.[5][6] It is a combination of empagliflozin and linagliptin.[5][6] It is taken by mouth.[5][6]
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| Combination of | |
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| Empagliflozin | SGLT2 inhibitor |
| Linagliptin | DPP-4 inhibitor |
| Clinical data | |
| Trade names | Glyxambi |
| AHFS/Drugs.com | Professional Drug Facts |
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| Routes of administration | By mouth |
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| Chemical and physical data | |
| Formula | C48H55ClN8O9 |
| Molar mass | 923.47 g·mol−1 |
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The most common side effects include urinary infections, nasopharyngitis, and upper respiratory tract infections .[5][6]
It was approved for use in the United States in January 2015,[7][8] for use in the European Union in November 2016,[6] and for use in Australia in December 2016.[2]
Medical uses
In the United States empagliflozin/linagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus and to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease.[5]
In the European Union empagliflozin/linagliptin is indicated in adults aged 18 years and older with type 2 diabetes mellitus:[6]
- to improve glycemic control when metformin and/or sulphonylurea (SU) and empagliflozin or linagliptin do not provide adequate glycemic control;[6]
- when already being treated with the free combination of empagliflozin and linagliptin.[6]
Adverse effects
The most common side effects include urinary infections, nasopharyngitis, and upper respiratory tract infections .[5][6] The most serious side effects include ketoacidosis (high blood levels of acids called ‘ketoacids’), pancreatitis (inflammation of the pancreas), hypersensitivity (allergic reactions) and hypoglycaemia (low blood sugar levels).[6]
History
The combination preparation was developed and is marketed by Boehringer Ingelheim and Eli Lilly and Company under the brand name Glyxambi.[9]
