Grancalcin

Grancalcin is a protein that in humans is encoded by the GCA gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesGCA, GCL, grancalcin

External IDsOMIM: 607030; MGI: 1918521; HomoloGene: 22702; GeneCards: GCA; OMA:GCA - orthologs

Chr.Chromosome 2 (human)^[1]

Quick facts GCA, Available structures ...

GCA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F4O, 1F4Q, 1K94, 1K95
Identifiers
Aliases	GCA, GCL, grancalcin
External IDs	OMIM: 607030; MGI: 1918521; HomoloGene: 22702; GeneCards: GCA; OMA:GCA - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.2 Start 162,318,840 bp[1] End 162,371,595 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.3 Start 62,494,629 bp[2] End 62,524,453 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood bone marrow bone marrow cell trabecular bone granulocyte spleen germinal epithelium C1 segment right lung Top expressed in granulocyte lumbar spinal ganglion morula pineal gland primary motor cortex olfactory epithelium seminal vesicula sciatic nerve ventricular zone retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity metal ion binding calcium-dependent cysteine-type endopeptidase activity protein heterodimerization activity calcium ion binding Cellular component plasma membrane extracellular exosome membrane extracellular region cytosol azurophil granule lumen cytoplasm Biological process membrane fusion proteolysis neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25801 227960 Ensembl ENSG00000115271 ENSMUSG00000026893 UniProt P28676 Q8VC88 RefSeq (mRNA) NM_012198 NM_001330265 NM_001330266 NM_001330267 NM_001330268 NM_001330270 NM_001330271 NM_145523 RefSeq (protein) NP_001317194 NP_001317195 NP_001317196 NP_001317197 NP_001317199 NP_001317200 NP_036330 NP_663498 Location (UCSC) Chr 2: 162.32 – 162.37 Mb Chr 2: 62.49 – 62.52 Mb PubMed search [3] [4]
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This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.^[8]