Gusacitinib

CAS Number

• 1425381-60-7

PubChem CID

• 71269142

DrugBank

• DB15670

ChemSpider

• 71117451

Gusacitinib

Identifiers
IUPAC name 2-[1-[4-[4-(4-hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile
CAS Number	1425381-60-7
PubChem CID	71269142
DrugBank	DB15670
ChemSpider	71117451
UNII	4801QYW816
KEGG	D11676
ChEMBL	ChEMBL4594275
Chemical and physical data
Formula	C24H28N8O2
Molar mass	460.542 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O
InChI InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29) Key:NLFLXLJXEIUQDL-UHFFFAOYSA-N

Gusacitinib (ASN002) is an investigational drug which acts as a pan-Janus kinase inhibitor, binding with similar affinity at JAK1, JAK2, JAK3 and TYK2, and also inhibiting spleen tyrosine kinase (SYK).^[1] It is taken orally and was developed for the treatment of eczema and dermatitis.^[2][3][4]