H2AFV

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesH2AZ2, H2A.Z-2, H2AV, H2A histone family member V, H2A.Z variant histone 2, H2AFV

External IDsMGI: 1924855; HomoloGene: 83271; GeneCards: H2AZ2; OMA:H2AZ2 - orthologs

Chr.Chromosome 7 (human)^[1]

Quick facts H2AZ2, Available structures ...

H2AZ2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WAA
Identifiers
Aliases	H2AZ2, H2A.Z-2, H2AV, H2A histone family member V, H2A.Z variant histone 2, H2AFV
External IDs	MGI: 1924855; HomoloGene: 83271; GeneCards: H2AZ2; OMA:H2AZ2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,826,791 bp[1] End 44,848,087 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 6,377,229 bp[2] End 6,394,443 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence optic nerve rectum mucosa of transverse colon right ventricle epithelium of colon endothelial cell left ventricle Achilles tendon Top expressed in Ileal epithelium medial ganglionic eminence ventricular zone maxillary prominence mandibular prominence endocardial cushion abdominal wall somite migratory enteric neural crest cell thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein heterodimerization activity molecular function Cellular component nucleosome extracellular exosome nucleus chromosome Biological process chromatin organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94239 77605 Ensembl ENSG00000105968 ENSMUSG00000041126 UniProt Q71UI9 Q3THW5 RefSeq (mRNA) NM_201517 NM_012412 NM_138635 NM_201436 NM_201516 NM_029938 NM_001347064 RefSeq (protein) NP_036544 NP_619541 NP_958844 NP_958924 NP_958925 NP_001333993 NP_084214 Location (UCSC) Chr 7: 44.83 – 44.85 Mb Chr 11: 6.38 – 6.39 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcripts have been identified for this gene.^[5]