HIST1H2BK

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesH2BC12, H2B/S, H2BFAiii, H2BFT, H2BK, histone cluster 1, H2bk, histone cluster 1 H2B family member k, H2B clustered histone 12, HIST1H2BK

External IDsOMIM: 615045; MGI: 2448399; HomoloGene: 135980; GeneCards: H2BC12; OMA:H2BC12 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H2BC12, Available structures ...

H2BC12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CV5
Identifiers
Aliases	H2BC12, H2B/S, H2BFAiii, H2BFT, H2BK, histone cluster 1, H2bk, histone cluster 1 H2B family member k, H2B clustered histone 12, HIST1H2BK
External IDs	OMIM: 615045; MGI: 2448399; HomoloGene: 135980; GeneCards: H2BC12; OMA:H2BC12 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,146,361 bp[1] End 27,146,855 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 22,220,040 bp[2] End 22,220,515 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell monocyte blood Achilles tendon placenta mucosa of transverse colon spleen gonad prostate fallopian tube Top expressed in uterus zygote secondary oocyte primary oocyte white adipose tissue bone marrow adrenal gland spermatid urinary bladder embryo More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein heterodimerization activity molecular function Cellular component nucleoplasm nucleosome nucleus chromosome extracellular space cytosol Biological process nucleosome assembly innate immune response in mucosa defense response to bacterium protein ubiquitination antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85236 319184 Ensembl ENSG00000197903 ENSMUSG00000062727 UniProt O60814 Q8CGP1 RefSeq (mRNA) NM_080593 NM_001312653 NM_175665 RefSeq (protein) NP_001299582 NP_542160 NP_783596 Location (UCSC) Chr 6: 27.15 – 27.15 Mb Chr 13: 22.22 – 22.22 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.^[6]