HAGH

Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGH gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesHAGH, GLO2, GLX2, GLXII, HAGH1, hydroxyacylglutathione hydrolase

External IDsOMIM: 138760; MGI: 95745; HomoloGene: 3890; GeneCards: HAGH; OMA:HAGH - orthologs

Chr.Chromosome 16 (human)^[1]

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HAGH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QH3, 1QH5
Identifiers
Aliases	HAGH, GLO2, GLX2, GLXII, HAGH1, hydroxyacylglutathione hydrolase
External IDs	OMIM: 138760; MGI: 95745; HomoloGene: 3890; GeneCards: HAGH; OMA:HAGH - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,795,620 bp[1] End 1,827,157 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.53 cM Start 25,059,117 bp[2] End 25,083,424 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lobe of liver right adrenal gland right adrenal cortex left adrenal gland gastrocnemius muscle left adrenal cortex prefrontal cortex muscle of thigh left testis Top expressed in spermatid right kidney spermatocyte left lobe of liver blood proximal tubule seminiferous tubule human kidney facial motor nucleus tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydroxyacylglutathione hydrolase activity protein binding hydrolase activity metal ion binding Cellular component cytoplasm cytosol mitochondrial matrix mitochondrion Biological process methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione glutathione biosynthetic process pyruvate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3029 14651 Ensembl ENSG00000063854 ENSMUSG00000024158 UniProt Q16775 Q99KB8 RefSeq (mRNA) NM_001040427 NM_001286249 NM_005326 NM_001363912 NM_001363914 NM_001159626 NM_024284 RefSeq (protein) NP_001035517 NP_001273178 NP_005317 NP_001350841 NP_001350843 NP_001153098 NP_077246 Location (UCSC) Chr 16: 1.8 – 1.83 Mb Chr 17: 25.06 – 25.08 Mb PubMed search [3] [4]
Wikidata
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The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.^[7]