HAP2
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| Male gamete fusion factor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | HAP2-GCS1 | ||||||||
| Pfam | PF10699 | ||||||||
| InterPro | IPR018928 | ||||||||
| |||||||||
HAP2 (hapless 2), also known as GCS1 (generative cell-specific protein 1), is a family of membrane fusion proteins found in the sperm cell of diverse eukaryotes including Toxoplasma, thale cress, and fruit flies. This protein is essential for gamete fusion, and therefore fertilization, in these organisms.[1]
By eukaryotic taxonomy, it is found in:
- Plant in the broad sense (Archaeplastida)
- Land plants (pollen – "male" gamete) - thale cress, numerous other species including rice[1]
- Green algae ("minus" mating type) - Chlamydomonas
- Red algae - Cyanidioschyzon [2]
- Alveolates
- Apicomplexans (male gametocytes)
- Ciliophorans - Tetrahymena[1]
- Euglenozoans - Trypanosoma[1]
- Amorphea
- Opisthokonta
- Animals
- Cnidarians - Hydra[1]
- Arthropods - Insects - fruit flies and bees[1]
- Acorn worms - Saccoglossus[1]
- Animals
- Amoebozoa - Dictyostelium discoideum slime mold (in a gene-duplicated setup with 3 mating types)[3][4]
- Opisthokonta
For a full list of organisms in which it occurs, consult InterPro #IPR018928 - taxonomy.