HECW1

HECW1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L4H
Identifiers
Aliases	HECW1, NEDL1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
External IDs	OMIM: 610384; MGI: 2444115; HomoloGene: 9004; GeneCards: HECW1; OMA:HECW1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	43,566,001 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	14,697,813 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; primary visual cortex; ; testicle; ; ganglionic eminence; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; superior frontal gyrus; ; pons;
	Top expressed in
	medial dorsal nucleus; ; facial motor nucleus; ; primary motor cortex; ; anterior horn of spinal cord; ; central gray substance of midbrain; ; medial geniculate nucleus; ; medial vestibular nucleus; ; prefrontal cortex; ; trigeminal ganglion; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; ubiquitin-protein transferase activity; ubiquitin protein ligase activity;
Cellular component	cytosol; cytoplasm;
Biological process	negative regulation of canonical Wnt signaling pathway; protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; regulation of dendrite morphogenesis; negative regulation of sodium ion transmembrane transporter activity;
	Sources:Amigo / QuickGO
Orthologs
	23072
	94253
	ENSG00000002746
	ENSMUSG00000021301
	Q76N89
	Q8K4P8
	NM_001287059; NM_015052
	NM_001081348; NM_153130; NM_178809
	NP_001273988; NP_055867
	NP_001074817
	Wikidata
View/Edit Human	View/Edit Mouse

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene.^[5] In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.^[6]