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HELZ2

Human gene From Wikipedia, the free encyclopedia

Helicase with zinc finger 2 is a protein that in humans is encoded by the gene HELZ2 (previously PRIC285).[5]

AliasesHELZ2, PDIP-1, PRIC285, helicase with zinc finger 2
End63,574,239 bp[1]
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HELZ2
Identifiers
AliasesHELZ2, PDIP-1, PRIC285, helicase with zinc finger 2
External IDsOMIM: 611265; MGI: 2385169; GeneCards: HELZ2
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
3.1.13.1
5.6.2.6
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001037335
NM_033405

NM_183162

RefSeq (protein)

NP_001032412
NP_208384

NP_898985

Location (UCSC)Chr 20: 63.56 – 63.57 MbChr 2: 180.87 – 180.88 Mb
PubMed search[3][4]
Wikidata
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The protein encoded by this gene is a nuclear transcriptional co-activator for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARA). The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

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