HEXIM1

HEXIM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GD7, 3S9G
Identifiers
Aliases	HEXIM1, CLP1, EDG1, HIS1, MAQ1, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide inducible 1, HEXIM P-TEFb complex subunit 1
External IDs	OMIM: 607328; MGI: 2385923; HomoloGene: 31382; GeneCards: HEXIM1; OMA:HEXIM1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	45,152,099 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,010,551 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; middle temporal gyrus; ; gingival epithelium; ; germinal epithelium; ; kidney tubule; ; glomerulus; ; Brodmann area 23; ; placenta; ; metanephric glomerulus; ; amniotic fluid;
	Top expressed in
	gastrula; ; median eminence; ; adrenal gland; ; transitional epithelium of urinary bladder; ; lateral geniculate nucleus; ; ascending aorta; ; granulocyte; ; medial geniculate nucleus; ; ciliary body; ; central gray substance of midbrain;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; snRNA binding; 7SK snRNA binding; cyclin-dependent protein serine/threonine kinase inhibitor activity;
Cellular component	nucleoplasm; cytoplasm; nucleus;
Biological process	positive regulation of signal transduction by p53 class mediator; development of the heart; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; activation of innate immune response; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	10614
	192231
	ENSG00000186834
	ENSMUSG00000048878
	O94992
	Q8R409
	NM_006460
	NM_138753
	NP_006451
	NP_620092
	Wikidata
View/Edit Human	View/Edit Mouse

Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene.^[5]^[6]^[7]

PDBOrtholog search: PDBe RCSB

AliasesHEXIM1, CLP1, EDG1, HIS1, MAQ1, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide inducible 1, HEXIM P-TEFb complex subunit 1

External IDsOMIM: 607328; MGI: 2385923; HomoloGene: 31382; GeneCards: HEXIM1; OMA:HEXIM1 - orthologs

Chr.Chromosome 17 (human)^[1]

Quick facts Available structures, PDB ...

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[1]

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HEXIM1

Interactions

See also

References

Further reading

Related Articles

Related Articles

"MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner"

"An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb"

"Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"

"A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb"

"Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor"

"HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b"

"Inhibition of Tat activity by the HEXIM1 protein"