HEXIM1

HEXIM1
Identifiers
Aliases	HEXIM1, CLP1, EDG1, HIS1, MAQ1, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide inducible 1, HEXIM P-TEFb complex subunit 1
External IDs	OMIM: 607328; MGI: 2385923; GeneCards: HEXIM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GD7, 3S9G
Gene location (Human)
Chr.	Chromosome 17 (human)
End	45,152,099 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,010,551 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; middle temporal gyrus; ; gingival epithelium; ; germinal epithelium; ; kidney tubule; ; glomerulus; ; Brodmann area 23; ; placenta; ; metanephric glomerulus; ; amniotic fluid;
	Top expressed in
	gastrula; ; median eminence; ; adrenal gland; ; transitional epithelium of urinary bladder; ; lateral geniculate nucleus; ; ascending aorta; ; granulocyte; ; medial geniculate nucleus; ; ciliary body; ; central gray substance of midbrain;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; snRNA binding; 7SK snRNA binding; cyclin-dependent protein serine/threonine kinase inhibitor activity;
Cellular component	nucleoplasm; cytoplasm; nucleus;
Biological process	positive regulation of signal transduction by p53 class mediator; development of the heart; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; activation of innate immune response; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10614
	192231
	ENSG00000186834
	ENSMUSG00000048878
	O94992
	Q8R409
	NM_006460
	NM_138753
	NP_006451
	NP_620092
	Wikidata
View/Edit Human	View/Edit Mouse

Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene.^[5]^[6]^[7]

AliasesHEXIM1, CLP1, EDG1, HIS1, MAQ1, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide inducible 1, HEXIM P-TEFb complex subunit 1

External IDsOMIM: 607328; MGI: 2385923; GeneCards: HEXIM1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 17 (human)^[1]

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HEXIM1

Interactions

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Related Articles

"MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner"

"An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb"

"Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"

"A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb"

"Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor"

"HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b"

"Inhibition of Tat activity by the HEXIM1 protein"