HIST1H4J

Histone cluster 1, H4j is a protein that in humans is encoded by the HIST1H4J gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesH4C11, H4/e, H4F2iv, H4FE, dJ160A22.2, histone cluster 1, H4j, histone cluster 1 H4 family member j, H4 clustered histone 11, HIST1H4J, H4C5, H4C4, H4C9, H4C12, H4-16, H4C3, H4C13, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, TEVANED2

External IDsOMIM: 602826; MGI: 2448425; HomoloGene: 134492; GeneCards: H4C11; OMA:H4C11 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H4C11, Available structures ...

H4C11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	H4C11, H4/e, H4F2iv, H4FE, dJ160A22.2, histone cluster 1, H4j, histone cluster 1 H4 family member j, H4 clustered histone 11, HIST1H4J, H4C5, H4C4, H4C9, H4C12, H4-16, H4C3, H4C13, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, TEVANED2
External IDs	OMIM: 602826; MGI: 2448425; HomoloGene: 134492; GeneCards: H4C11; OMA:H4C11 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,824,092 bp[1] End 27,824,480 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,735,432 bp[2] End 23,735,822 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell testicle epithelium of colon gastric mucosa Achilles tendon tonsil ganglionic eminence olfactory zone of nasal mucosa ventricular zone skeletal muscle tissue Top expressed in uterus yolk sac bone marrow embryo embryo blastocyst morula spermatid thymus spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein domain specific binding protein binding protein heterodimerization activity DNA binding histone binding RNA binding Cellular component membrane chromosome nucleoplasm extracellular region nuclear chromosome nucleosome extracellular exosome nucleus extracellular matrix protein-containing complex Biological process telomere organization epigenetic maintenance of chromatin in transcription-competent conformation protein heterotetramerization negative regulation of megakaryocyte differentiation CENP-A containing chromatin assembly DNA replication-dependent chromatin assembly rDNA heterochromatin assembly negative regulation of gene expression, epigenetic DNA-templated transcription, initiation double-strand break repair via nonhomologous end joining beta-catenin-TCF complex assembly telomere capping nucleosome assembly regulation of gene silencing by miRNA regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8363 319157 Ensembl ENSG00000197238 ENSMUSG00000069274 UniProt P62805 P62806 RefSeq (mRNA) NM_021968 NM_175655 RefSeq (protein) NP_003537 NP_003486 NP_003535 NP_003539 NP_003531 NP_003536 NP_291074 NP_783587 NP_783588 NP_835499 NP_835500 NP_001182350 NP_835515 NP_783585 NP_783586 NP_835582 NP_835583 NP_783583 NP_694813 Location (UCSC) Chr 6: 27.82 – 27.82 Mb Chr 13: 23.74 – 23.74 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008].^[5]