HOCOMOCO
Database of human and mouse transcription factor binding sites
From Wikipedia, the free encyclopedia
HOCOMOCO[1][2] [3][4] is an open-access database providing curated and benchmarked binding motifs of human and mouse transcription factors. It captures the following data types: Homo sapiens (human) and Mus musculus (mouse) transcription factors, their DNA binding site motifs, and motif subtypes.
capturedTranscription factor binding profiles
laboratory: autosome.org
author: Vorontsov, Makeev, Kulakovskiy | |
| Content | |
|---|---|
| Description | Curated collection of binding models for human and mouse transcription factors |
| Data types captured | Transcription factor binding profiles |
| Organisms | Homo sapiens, Mus musculus
laboratory: autosome.org author: Vorontsov, Makeev, Kulakovskiy |
| Contact | |
| Primary citation | Vorontsov et al [1] |
| Access | |
| Website | HOCOMOCO |
Introduction
Transcription factors (TFs) are proteins that bind DNA and thus regulate the transcription process. The binding is sequence-specific. A sequence motif[5] is a model that describes the common pattern of the DNA binding sites[6] that a particular TF prefers to bind. One of the possible representations of the model is the Position-Weight Matrix (PWM).[7]
Organisms
Recognition
According to the Web of Science, the 2018 publication of HOCOMOCO [2] has been cited 396 times (as of January 2024). The publications [3][4] have been cited 144 and 151 times.