HOXB5

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.[5][6][7]

AliasesHOXB5, HHO.C10, HOX2, HOX2A, HU-1, Hox2.1, homeobox B5
End48,593,779 bp[1]
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HOXB5
Identifiers
AliasesHOXB5, HHO.C10, HOX2, HOX2A, HU-1, Hox2.1, homeobox B5
External IDsOMIM: 142960; MGI: 96186; HomoloGene: 37585; GeneCards: HOXB5; OMA:HOXB5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002147

NM_008268

RefSeq (protein)

NP_002138

NP_032294

Location (UCSC)Chr 17: 48.59 – 48.59 MbChr 11: 96.19 – 96.2 Mb
PubMed search[3][4]
Wikidata
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Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[7]

See also

References

Further reading

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