HOXB5
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.[5][6][7]
External IDsOMIM: 142960; MGI: 96186; HomoloGene: 37585; GeneCards: HOXB5; OMA:HOXB5 - orthologs
Function
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[7]