HOXD11

Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.^[5][6][7]

AliasesHOXD11, HOX4, HOX4F, homeobox D11

External IDsOMIM: 142986; MGI: 96203; HomoloGene: 7368; GeneCards: HOXD11; OMA:HOXD11 - orthologs

Chr.Chromosome 2 (human)^[1]

End176,109,754 bp^[1]

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HOXD11
Identifiers
Aliases	HOXD11, HOX4, HOX4F, homeobox D11
External IDs	OMIM: 142986; MGI: 96203; HomoloGene: 7368; GeneCards: HOXD11; OMA:HOXD11 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 176,104,216 bp[1] End 176,109,754 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 44.13 cM Start 74,509,901 bp[2] End 74,517,360 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus stromal cell of endometrium Achilles tendon urethra myometrium muscle layer of sigmoid colon gonad vagina ectocervix decidua Top expressed in tail of embryo uterus basal cell layer of epidermis genital tubercle granular layer of epidermis urethra male urethra stroma of kidney free upper limb sclerotome More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process multicellular organism development branching involved in ureteric bud morphogenesis regulation of transcription, DNA-templated dorsal/ventral pattern formation transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3237 15431 Ensembl ENSG00000128713 ENSMUSG00000042499 UniProt P31277 P23813 RefSeq (mRNA) NM_021192 NM_008273 RefSeq (protein) NP_067015 NP_032299 Location (UCSC) Chr 2: 176.1 – 176.11 Mb Chr 2: 74.51 – 74.52 Mb PubMed search [3] [4]
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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.^{[7][8][9][10]}