HOXD12

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.^[5][6][7]

AliasesHOXD12, HOX4H, homeobox D12

External IDsOMIM: 142988; MGI: 96204; HomoloGene: 7369; GeneCards: HOXD12; OMA:HOXD12 - orthologs

Chr.Chromosome 2 (human)^[1]

End176,102,489 bp^[1]

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HOXD12
Identifiers
Aliases	HOXD12, HOX4H, homeobox D12
External IDs	OMIM: 142988; MGI: 96204; HomoloGene: 7369; GeneCards: HOXD12; OMA:HOXD12 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 176,099,795 bp[1] End 176,102,489 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 44.13 cM Start 74,505,357 bp[2] End 74,508,049 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vagina muscle layer of sigmoid colon rectum ectocervix prostate canal of the cervix urinary bladder wall of uterus myometrium kidney Top expressed in genital tubercle urethra tail of embryo female urethra male urethra muscle layer of urethra hand epithelium of male urethra footplate sclerotome More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex Biological process pattern specification process multicellular organism development skeletal system development embryonic digit morphogenesis regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3238 15432 Ensembl ENSG00000170178 ENSMUSG00000001823 UniProt P35452 P23812 RefSeq (mRNA) NM_021193 NM_008274 RefSeq (protein) NP_067016 NP_032300 Location (UCSC) Chr 2: 176.1 – 176.1 Mb Chr 2: 74.51 – 74.51 Mb PubMed search [3] [4]
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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd12 gene plays a role in axial skeleton development and forelimb morphogenesis.^[8]