HP-505

HP-505
Identifiers
	IUPAC name 3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine];
CAS Number	59142-94-8;
PubChem CID	191510;
ChemSpider	166303;
ChEMBL	ChEMBL436281;
CompTox Dashboard (EPA)	DTXSID20974577 ;
Chemical and physical data
Formula	C18H19NO
Molar mass	265.356 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1(C2OC3(CCNCC3)C4=C2C=CC=C4)=CC=CC=C1;
	InChI InChI=1S/C18H19NO/c1-2-6-14(7-3-1)17-15-8-4-5-9-16(15)18(20-17)10-12-19-13-11-18/h1-9,17,19H,10-13H2; Key:ZFJQWOMHWFYLPD-UHFFFAOYSA-N;

HP-505 is a triple reuptake inhibitor that was investigated by Hoechst-Roussel Pharmaceuticals.^[1] In mice, HP-505 was a potent inhibitor of tetrabenazine-induced ptosis which may indicate antidepressant activity.^[2]

Synthesis

Identifiers

IUPAC name 3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine]
CAS Number	59142-94-8
PubChem CID	191510
ChemSpider	166303
ChEMBL	ChEMBL436281
CompTox Dashboard (EPA)	DTXSID20974577
Chemical and physical data
Formula	C₁₈H₁₉NO
Molar mass	265.356 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1(C2OC3(CCNCC3)C4=C2C=CC=C4)=CC=CC=C1
InChI InChI=1S/C18H19NO/c1-2-6-14(7-3-1)17-15-8-4-5-9-16(15)18(20-17)10-12-19-13-11-18/h1-9,17,19H,10-13H2 Key:ZFJQWOMHWFYLPD-UHFFFAOYSA-N