HPTP

HPTP
Clinical data
Drug class	Serotonergic and dopaminergic neurotoxin
Identifiers
	IUPAC name 4-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-1-(4-fluorophenyl)butan-1-one;
CAS Number	52669-92-8;
PubChem CID	171187;
ChemSpider	149659;
ChEBI	CHEBI:177523;
ChEMBL	ChEMBL3544895;
CompTox Dashboard (EPA)	DTXSID80200642 ;
Chemical and physical data
Formula	C21H21ClFNO
Molar mass	357.85 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CC=C1C2=CC=C(C=C2)Cl)CCCC(=O)C3=CC=C(C=C3)F;
	InChI InChI=1S/C21H21ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-11H,1-2,12-15H2; Key:ZNOLNAPJKOYTHY-UHFFFAOYSA-N;

HPTP is a monoaminergic neurotoxin related to MPTP.^[1]^[2]^[3]^[4] It is the dehydration product of haloperidol.^[1]^[2]^[4] The agent is specifically a dopaminergic and serotonergic neurotoxin.^[1] HPTP is a prodrug of HPP⁺, which mediates its monoaminergic neurotoxicity.^[1]^[2]^[4] This is analogous to how MPP⁺ mediates the neurotoxicity of MPTP.^[1]^[2]^[4] Other related compounds include RHPTP and RHPP⁺.^[5]