HSD17B8

Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesHSD17B8, D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8

External IDsOMIM: 601417; MGI: 95911; HomoloGene: 56588; GeneCards: HSD17B8; OMA:HSD17B8 - orthologs

EC number1.1.1.239

Quick facts Available structures, PDB ...

HSD17B8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PD6, 4CQL, 4CQM
Identifiers
Aliases	HSD17B8, D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8
External IDs	OMIM: 601417; MGI: 95911; HomoloGene: 56588; GeneCards: HSD17B8; OMA:HSD17B8 - orthologs
EC number	1.1.1.239
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 33,204,655 bp[1] End 33,206,831 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,245,007 bp[2] End 34,247,034 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right lobe of liver right uterine tube testicle mucosa of transverse colon right adrenal gland human kidney right adrenal cortex left lobe of thyroid gland right lobe of thyroid gland Top expressed in adrenal gland proximal tubule right kidney islet of Langerhans human kidney neural layer of retina granulocyte white adipose tissue bone marrow urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity estradiol 17-beta-dehydrogenase activity protein binding testosterone dehydrogenase (NAD+) activity 3-hydroxyacyl-CoA dehydrogenase activity 3-oxoacyl-[acyl-carrier-protein reductase (NADH) activity] NADH binding oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Cellular component plasma membrane mitochondrial envelope membrane mitochondrion mitochondrial matrix Biological process estrogen biosynthetic process estrogen metabolic process androgen metabolic process fatty acid metabolic process lipid metabolism steroid biosynthetic process fatty acid biosynthetic process protein heterotetramerization fatty-acyl-CoA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7923 14979 Ensembl ENSG00000204228 ENSG00000228357 ENSG00000225312 ENSG00000232357 ENSG00000112474 ENSG00000228712 ENSMUSG00000073422 UniProt Q92506 P50171 RefSeq (mRNA) NM_014234 NM_013543 RefSeq (protein) NP_055049 NP_038571 Location (UCSC) Chr 6: 33.2 – 33.21 Mb Chr 17: 34.25 – 34.25 Mb PubMed search [3] [4]
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In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.^[7]