HSUR
RNA family
From Wikipedia, the free encyclopedia
HSURs (Herpesvirus saimiri U RNAs) are viral small regulatory RNAs. They are found in Herpesvirus saimiri which is responsible for aggressive T-cell leukemias in primates. They are nuclear RNAs which bind host proteins to form small nuclear ribonucleoproteins (snRNPs).[1] The RNAs are 114–143 nucleotides in length and the HSUR family has been subdivided into HSURs numbered 1 to 7.[2] The function of HSURs has not yet been identified; they do not affect transcription so are thought to act post-transcriptionally, potentially influencing the stability of host mRNAs.[1]
| HSUR1 | |
|---|---|
Conserved secondary structure of HSUR1. | |
| Identifiers | |
| Symbol | HSUR1 |
| Rfam | RF01802 |
| Other data | |
| RNA type | snRNA |
| Domain(s) | Herpesvirus saimiri, Herpesvirus ateles |
| PDB structures | PDBe |
| HSUR2 | |
|---|---|
 Conserved secondary structure of HSUR2. | |
| Identifiers | |
| Symbol | HSUR2 |
| Rfam | RF01802 |
| Other data | |
| RNA type | snRNA |
| Domain(s) | Herpesvirus saimiri, Herpesvirus ateles |
| PDB structures | PDBe |
HSUR1 and 2 are the most conserved members of the family within HSV subgroups. HSUR1 has been shown to bind the host heterogeneous ribonucleoprotein particle protein hnRNPD in vivo.[3] Other HSURs bind HuR/ELAVL1.[2] They are transcribed by RNA polymerase II with promoters similar to that of U RNAs[1]
Features shared by all HSURs include:[1]
- 5′-trimethylguanosine caps
- 3′ terminal stem-loops
- canonical Sm protein-binding site (AUUUUUG)
A proposed role for HSURs is that they use the RNA interference (RNAi) pathway to manipulate host-cell gene expression. One identified miRNA which responds to HSURs is miR-27.[4]