Hachiro Sugimoto
From Wikipedia, the free encyclopedia
Hachiro Sugimoto (杉本 八郎, Sugimoto Hachirō) is a Japanese chemist and pharmacologist, known for his discovery of Donepezil.
Sugimoto's research on E2020 (now called Donepezil), an acetylcholinesterase inhibitor, first began at Eisai's Tsukuba Research Laboratories in 1983,[1] because his mother suffered from dementia.[2] At that time, there was a hypothesis suggested that acetylcholines were closely linked to abnormal decreases in memory function in patients with Alzheimer's disease.[2] His research group was finally able to successfully create Donepezil with a promising enough profile for the compound to become a drug candidate.[2]
