Halometasone

Halometasone is a potent (Group III) synthetic tri-halogenated corticosteroid for topical application possessing pronounced anti-inflammatory, antiexudative, antiepidermoplastic, antiallergic, and antipruritic properties. It has been approved in many European countries including Spain, Germany, Switzerland, Austria, Netherlands, Belgium, and Portugal and other regions such as China, Hong Kong, Turkey, Israel, South Africa and India.

Trade namesSicorten

Other names(6S,8S,9R,10S,11S,13S,16R,17R)-2-chloro-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxy-acetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

AHFS/Drugs.comInternational Drug Names

Routes of
administrationTopical

Quick facts Clinical data, Trade names ...

Halometasone

Clinical data
Trade names	Sicorten
Other names	(6S,8S,9R,10S,11S,13S,16R,17R)-2-chloro-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxy-acetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical
ATC code	D07AC12 (WHO)
Identifiers
IUPAC name (6α,11β,16α)-2-Chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS Number	50629-82-8 Y
PubChem CID	9846332
ChemSpider	8022046 N
UNII	J69Z9UU41Z
ChEMBL	ChEMBL1587228 N
CompTox Dashboard (EPA)	DTXSID1048382
ECHA InfoCard	100.051.496
Chemical and physical data
Formula	C22H27ClF2O5
Molar mass	444.90 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)C(\Cl)=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
InChI InChI=1S/C22H27ClF2O5/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26/h6-7,10-12,15,17,26,28,30H,4-5,8-9H2,1-3H3/t10-,11+,12+,15+,17+,19+,20+,21+,22+/m1/s1 N Key:GGXMRPUKBWXVHE-MIHLVHIWSA-N N
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It has been used to treat chronic psoriasis vulgaris^[1] and non-infected acute eczematous dermatoses (eczema).^[2] One study demonstrated that 0.05% halometasone cream was more effective than 0.05% betamethasone cream in treating dermatitis, though both were well tolerated, with no systemic adverse effects reported.^[3]