Hans Thoenen

While testing dopamine analogues at Hoffman-LaRoche, he was surprised by the toxicity of 6-hydroxydopamine on sympathetic nerves and investigated its mechanisms of action. Its selective effect on dopaminergic neurons has made it a useful tool in animal models of Parkinson's disease.^[2]

This line of research had an unexpected payoff. While working with Axelrod at NIMH, Thoenen discovered that repeated stimulation of the adrenal medulla led to increased levels of the monoamine synthesis enzyme tyrosine hydroxylase. Trans-synaptic enzyme induction had never previously been detected: it transpired that it was a general phenomenon.^[2]

At Basel, his attention turned to nerve growth factor and other neurotrophins. His laboratory made a series of groundbreaking contributions to the field, including the cloning of brain derived neurotrophic factor and ciliary neurotrophic factor. Almost all his subsequent research focused on this class of proteins, the elucidation of their physiological functions, and the factors that influenced their expression and release – including other growth factors, the presynaptic release of neurotransmitters, glucocorticosteroids, and stress.^[2] His work has been instrumental in demonstrating the importance of neurotrophins for brain plasticity (the formation and pruning of synaptic connections in, for example, learning and memory), and has pursued their relevance for remediating nerve damage and dementia.^[3]

Thoenen won the Feldberg Award (1980),^[4] the Cloëtta Prize (1985),^[5] the Charles A. Dana Award for Pioneering Achievement in Health (1994) and the Neuronal Plasticity Prize (1994).^[6] He received the Ralph W. Gerard Prize in Neuroscience of the Society for Neuroscience (1995),^[7] the ECNP Neuropsychopharmacology Award (1996), and the Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (1997)^[8] jointly with Eric M. Shooter. He was awarded the Ernst Jung Gold Medal in 2007.^[9] He was a member of the German Academy of Sciences Leopoldina^[10] and a foreign member of the National Academy of Sciences.^[11] He received honorary doctorates from the Universities of Würzburg and Zurich.^[1]