Henagliflozin

Henagliflozin
Clinical data
Trade names	Rui Qin; 瑞沁
Other names	SHR3824; SHR-3824
Legal status
Legal status	Rx in China;
Identifiers
	IUPAC name (1R,2S,3S,4R,5R)-5-[4-Chloro-3-[(4-ethoxy-3-fluorophenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol;
CAS Number	1623804-44-3;
PubChem CID	56832738;
DrugBank	DB11939;
ChemSpider	52083652;
UNII	21P2M98388;
ChEMBL	ChEMBL4297431;
Chemical and physical data
Formula	C22H24ClFO7
Molar mass	454.88 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC1=C(C=C(C=C1)CC2=C(C=CC(=C2)[C@]34[C@@H]([C@H]([C@@H]([C@](O3)(CO4)CO)O)O)O)Cl)F;
	InChI InChI=1S/C22H24ClFO7/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3/t18-,19-,20+,21+,22+/m0/s1; Key:HYTPDMFFHVZBOR-VNXMGFANSA-N;

Henagliflozin is a pharmaceutical drug for the treatment of type 2 diabetes.^[1] In China, it is approved for adult patients with type 2 diabetes to improve the glycemic control.^[2]^[3]

Trade namesRui Qin; 瑞沁

Other namesSHR3824; SHR-3824

Legal status

Rx in China

CAS Number

1623804-44-3

Quick facts Clinical data, Trade names ...

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Henagliflozin, like other drugs of the gliflozin class, inhibits the transporter protein sodium/glucose cotransporter 2 (SGLT2) which leads to a reduction in blood glucose levels.^[4]

In a 26-week placebo-controlled trial of type 2 diabetics, telomere length significantly lengthened, the IGF-1 pathway was inhibited, and immune system function was improved in the henagliflozin group compared to the placebo group.^[5]

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[2]

[3]

[4]

[5]

Henagliflozin

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