On March 23, 1903 the original building on the Christian University (today's Culver–Stockton) campus, "Old Main", which predated the American Civil War, was destroyed by fire.[5] Appreciating the importance of the college to the town, citizens rallied to its aid. In addition to opening up local churches and other buildings for use as temporary classrooms Canton residents raised $15,000 in just ten days to help the college rebuild.[5] The college was able to salvage some stone and brick from the Old Main rubble, and using it plus the community's donation, an $8,000 insurance payout, and a $15,000 loan to build the current Henderson Hall.[5]
Within a few short months the rubble had been cleared away and construction on the new Henderson Hall began on August 10, 1903. Knowing time was critical to the college and the town, construction workers labored through adverse Missouri winter weather to complete the basic building by the following spring. Even with using salvaged stone and brick from the original, the college still lacked funds to provide for amenities in the Henderson Hall when it was officially occupied on May 15, 1904. Further, the construction loan needed to be repaid so in August 1904 famed orator and political figure William Jennings Bryan spoke in Canton to help raise additional funds.[3] The building at first housed men's and women's gymnasiums, a large assembly hall, dining room and various administrative offices. In 1915 the first of several remodeling projects was undertaken, adding science labs and a library.[5] Further repairs and renovations took place in 1937, 1948, 1960, and 1968, changing both the purpose and interior look of the building.[5] As mentioned earlier, in 2003 a tornado struck the Culver-Stockton campus, destroying the Henderson Hall dome, itself a 1960 replacement for the 1903-4 original. The dome was once again replaced and Henderson Hall continues today to serve as a campus centerpiece, housing primarily administrative offices but also some classroom space.