Homofenazine
Antipsychotic medication
From Wikipedia, the free encyclopedia
Homofenazine is an antipsychotic drug of the phenothiazines class.[5] It was synthesized by Wilhelm Schuler and colleagues at Degussa.[8][9] In 1966, it was released in Belgium under the brand name Pasaden.[1] At some point, it was quietly discontinued and is no longer marketed.[citation needed]
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| Trade names | Pasaden,[1][2] Oldagen (in Argentina)[3][4] |
| Other names | HFZ[5] |
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| Formula | C23H28F3N3OS |
| Molar mass | 451.55 g·mol−1 |
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| Boiling point | 230–240 °C (446–464 °F) [7] |
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Synthesis
The alkylation between 2-(Trifluoromethyl)Phenothiazine [92-30-8] (1) and 1-(3-bromopropyl)-1,4-diazepane (2) led to 10-[3-(1,4-diazepan-1-yl)propyl]-2-(trifluoromethyl)phenothiazine, CID:110174391 (3). Further alkylation with 2-Chloroethanol [107-07-3] (4) completed the synthesis of homofenazine (5).