Homoisocitrate dehydrogenase
Enzyme
From Wikipedia, the free encyclopedia
In enzymology, homoisocitrate dehydrogenase (EC 1.1.1.87) is an enzyme that catalyzes the chemical reaction
-1-Hydroxy-1,2,4-butanetricarboxylic_acid.svg)
| homoisocitrate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Homoisocitrate dehydrogenase tetramer, Thermus thermophilus | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.87 | ||||||||
| CAS no. | 37250-23-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The two substrates of this enzyme are (-)-homoisocitric acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2-oxoadipic acid, carbon dioxide, reduced NADH, and a proton.[1][2][3][4]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating). Other names in common use include 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, homoisocitric dehydrogenase, (â)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase, (decarboxylating), 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), and HICDH. This enzyme participates in lysine biosynthesis.
