Hydroxyacid-oxoacid transhydrogenase
From Wikipedia, the free encyclopedia
In enzymology, hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24) is an enzyme that catalyzes the chemical reaction
-2-hydroxyglutaric_acid.svg)
-3-hydroxybutyric_acid.svg)
| hydroxyacid-oxoacid transhydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.99.24 | ||||||||
| CAS no. | 117698-31-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The two substrates of this enzyme are (S)-3-hydroxybutyric acid and α-ketoglutaric acid. Its products are acetoacetic acid and (R)-2-hydroxyglutaric acid.[1]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase. This enzyme is also called transhydrogenase, hydroxy acid-oxo acid.[2]
