Hydroxymethylglutaryl-CoA reductase (NADPH)
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In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) is an enzyme that catalyzes the chemical reaction
-3-Hydroxy-3-methylglutaryl-CoA.svg)
-Mevalonat.svg)
| hydroxymethylglutaryl-CoA reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 HMG-CoA reductase tetramer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.34 | ||||||||
| CAS no. | 9028-35-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are (R)-mevalonate, coenzyme A (CoA), and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are (S)-3-hydroxy-3-methylglutaryl-CoA, reduced NADPH, and two protons.[1][2][3][4]
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.
Nomenclature
The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include:
- hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
- 3-hydroxy-3-methylglutaryl-CoA reductase
- β-hydroxy-β-methylglutaryl coenzyme A reductase
- hydroxymethylglutaryl CoA reductase (NADPH)
- S-3-hydroxy-3-methylglutaryl-CoA reductase
- NADPH-hydroxymethylglutaryl-CoA reductase
- HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
- hydroxymethylglutaryl-CoA reductase (NADPH2).
