ICI-118,551

ICI-118,551 is a selective β₂ adrenergic receptor (adrenoreceptor) antagonist or beta blocker.^[1][2] ICI binds to the β₂ subtype with at least 100 times greater affinity than β₁ or β₃, the two other known subtypes of the beta adrenoceptor.^[3][4] The compound was developed by Imperial Chemical Industries, which was acquired by AkzoNobel in 2008.

Quick facts Names, Identifiers ...

ICI-118,551

Names
IUPAC name 3-(isopropylamino)-1-[(7-methyl-4-indanyl)oxy]butan-2-ol
Identifiers
CAS Number	72795-26-7 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:91879
ChEMBL	ChEMBL513389 N
ChemSpider	3554
EC Number	998-334-3
MeSH	ICI+118551
PubChem CID	3682
UNII	46OL1UC10R Y
CompTox Dashboard (EPA)	DTXSID70874977
InChI InChI=1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3 Key: VFIDUCMKNJIJTO-UHFFFAOYSA-N
SMILES CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O
Properties
Chemical formula	C17H27NO2
Molar mass	277.402 g/mol
Hazards
GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Close

ICI-118,551 has no known therapeutic use in humans although it has been used widely in research to understand the action of the β₂ adrenergic receptor, as few other specific antagonists for this receptor are known.^[5] ICI-118,551 has been used in pre-clinical studies using murine models.^[6][7][8] When dissolved in saline, the compound crosses the blood–brain barrier. Common systemic doses used in rodent research are 0.5 or 1 mg/kg although efficacy has been demonstrated at doses as low as 0.0001 mg/kg (100 ng/kg) in rhesus monkeys.^[9] Doses up to 20 mg/kg have been used without toxicity. At room temperature in saline, the ICI 118,551 hydrochloride is soluble to at least 2.5 mg/mL.