IFNB1

IFNB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AU1
Identifiers
Aliases	IFNB1, IFB, IFF, IFNB, IFN-beta, interferon beta 1
External IDs	OMIM: 147640; MGI: 107657; HomoloGene: 1640; GeneCards: IFNB1; OMA:IFNB1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	21,077,942 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	88,441,011 bp
RNA expression pattern
	Top expressed in
	gonad; ; bone; ; granulocyte; ; epithelium of colon; ; bone marrow; ; islet of Langerhans; ; upper lobe of lung; ; upper lobe of left lung; ; left lobe of thyroid gland;
	Top expressed in
	sternocleidomastoid muscle; ; triceps brachii muscle; ; temporal muscle; ; digastric muscle; ; artery; ; skin of abdomen; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; cytokine receptor binding; chloramphenicol O-acetyltransferase activity; type I interferon receptor binding;
Cellular component	extracellular space; extracellular region;
Biological process	positive regulation of peptidyl-serine phosphorylation of STAT protein; blood coagulation; B cell differentiation; cellular response to interferon-beta; regulation of MHC class I biosynthetic process; negative regulation of viral genome replication; natural killer cell activation; B cell activation involved in immune response; positive regulation of apoptotic signaling pathway; cell surface receptor signaling pathway; natural killer cell activation involved in immune response; response to exogenous dsRNA; response to virus; T cell activation involved in immune response; positive regulation of transcription by RNA polymerase II; defense response; negative regulation of T cell differentiation; positive regulation of innate immune response; cellular response to exogenous dsRNA; negative regulation of T-helper 2 cell cytokine production; defense response to virus; type I interferon signaling pathway; regulation of signaling receptor activity; humoral immune response; B cell proliferation; adaptive immune response; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3456
	15977
	ENSG00000171855
	ENSMUSG00000048806
	P01574
	P01575
	NM_002176
	NM_010510
	NP_002167
	NP_034640
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.^[5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.