IGF2BP1

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesIGF2BP1, CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1

External IDsOMIM: 608288; MGI: 1890357; HomoloGene: 4772; GeneCards: IGF2BP1; OMA:IGF2BP1 - orthologs

Chr.Chromosome 17 (human)^[1]

Quick facts Available structures, PDB ...

IGF2BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KRM
Identifiers
Aliases	IGF2BP1, CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1
External IDs	OMIM: 608288; MGI: 1890357; HomoloGene: 4772; GeneCards: IGF2BP1; OMA:IGF2BP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,997,385 bp[1] End 49,056,145 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.08 cM Start 95,957,163 bp[2] End 96,005,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle ganglionic eminence gonad ventricular zone stromal cell of endometrium buccal mucosa cell right testis left testis placenta retinal pigment epithelium Top expressed in tail of embryo abdominal wall hand epiblast mandibular prominence maxillary prominence primitive streak genital tubercle yolk sac embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation regulator activity mRNA 3'-UTR binding protein binding nucleic acid binding mRNA 5'-UTR binding mRNA binding RNA binding Cellular component cytoplasm CRD-mediated mRNA stability complex cell projection filopodium growth cone dendritic spine axon dendrite perinuclear region of cytoplasm cytoplasmic stress granule nucleus lamellipodium nucleoplasm cytosol ribonucleoprotein complex Biological process CRD-mediated mRNA stabilization mRNA transport negative regulation of translation pallium cell proliferation in forebrain neuronal stem cell population maintenance RNA localization regulation of translation regulation of mRNA stability involved in response to stress regulation of mRNA stability transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10642 140486 Ensembl ENSG00000159217 ENSMUSG00000013415 UniProt Q9NZI8 O88477 RefSeq (mRNA) NM_001160423 NM_006546 NM_009951 RefSeq (protein) NP_001153895 NP_006537 NP_034081 NP_001388383 NP_001388384 NP_001388385 NP_001388386 Location (UCSC) Chr 17: 49 – 49.06 Mb Chr 11: 95.96 – 96.01 Mb PubMed search [3] [4]
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This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.^[7]