IL1RAPL2

X-linked interleukin-1 receptor accessory protein-like 2 is a protein that in humans is encoded by the IL1RAPL2 gene.^[5][6]

AliasesIL1RAPL2, IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1, interleukin 1 receptor accessory protein like 2

External IDsOMIM: 300277; MGI: 1913106; HomoloGene: 9681; GeneCards: IL1RAPL2; OMA:IL1RAPL2 - orthologs

Chr.X chromosome (human)^[1]

End105,767,829 bp^[1]

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IL1RAPL2
Identifiers
Aliases	IL1RAPL2, IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1, interleukin 1 receptor accessory protein like 2
External IDs	OMIM: 300277; MGI: 1913106; HomoloGene: 9681; GeneCards: IL1RAPL2; OMA:IL1RAPL2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.3 Start 104,566,199 bp[1] End 105,767,829 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F1 Start 136,471,357 bp[2] End 137,747,695 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad prefrontal cortex right lobe of liver skin of hip Brodmann area 9 placenta urinary bladder gallbladder primary visual cortex Top expressed in multiform layer of neocortex internal granular layer Purkinje cell external pyramidal layer of neocortex embryo internal pyramidal layer of neocortex barrel cortex primary visual cortex median eminence superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function interleukin-1, type II, blocking receptor activity interleukin-1 receptor activity Cellular component integral component of membrane membrane plasma membrane glutamatergic synapse Biological process central nervous system development signal transduction cytokine-mediated signaling pathway regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26280 60367 Ensembl ENSG00000189108 ENSMUSG00000059203 UniProt Q9NP60 Q9ERS6 RefSeq (mRNA) NM_017416 NM_030688 RefSeq (protein) NP_059112 NP_109613 Location (UCSC) Chr X: 104.57 – 105.77 Mb Chr X: 136.47 – 137.75 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic intellectual disability.^[6]