IMPDH1

IMPDH1
Identifiers
Aliases	IMPDH1, IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608, IMP (inosine 5'-monophosphate) dehydrogenase 1, inosine monophosphate dehydrogenase 1
External IDs	OMIM: 146690; MGI: 96567; GeneCards: IMPDH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JCN
Enzyme activity
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,410,252 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	29,216,363 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; body of stomach; ; stromal cell of endometrium; ; blood; ; spleen; ; gastric mucosa; ; apex of heart; ; tibial nerve; ; upper lobe of left lung;
	Top expressed in
	neural layer of retina; ; olfactory epithelium; ; thymus; ; retinal pigment epithelium; ; morula; ; superior frontal gyrus; ; lumbar spinal ganglion; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; catalytic activity; RNA binding; nucleic acid binding; oxidoreductase activity; DNA binding; IMP dehydrogenase activity; nucleotide binding;
Cellular component	cytoplasm; nucleus; extracellular region; cytosol; secretory granule lumen; azurophil granule lumen; ficolin-1-rich granule lumen;
Biological process	purine nucleotide biosynthetic process; purine ribonucleoside monophosphate biosynthetic process; lymphocyte proliferation; GMP biosynthetic process; GTP biosynthetic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	3614
	23917
	ENSG00000106348
	ENSMUSG00000003500
	P20839
	P50096
NM_000883; NM_001102605; NM_001142573; NM_001142574; NM_001142575;
	NM_001142576; NM_001304521; NM_183243
	NM_011829; NM_001302933; NM_001302934
NP_000874; NP_001096075; NP_001136045; NP_001136046; NP_001136047;
	NP_001136048; NP_001291450; NP_899066
	NP_001289862; NP_001289863; NP_035959
	Wikidata
View/Edit Human	View/Edit Mouse

Inosine-5'-monophosphate dehydrogenase 1, also known as IMP dehydrogenase 1, is an enzyme that in humans is encoded by the IMPDH1 gene.^[5]^[6]