Integrin beta 5
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[5][6]
Interactions
Functions
ITGB5 encodes a subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5 is a receptor for the extracellular matrix protein Vitronectin and can form both focal adhesions and reticular adhesions. [10]
Clinical significance
Research
Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[11]
