Integrin beta 5
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[5][6]
External IDsOMIM: 147561; MGI: 96614; HomoloGene: 20511; GeneCards: ITGB5; OMA:ITGB5 - orthologs
Interactions
Functions
ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.[10]
Clinical significance
Research
Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[11]
