Intelectin-1

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene.^[5][6][7] Intelectin-1 functions both as a receptor for bacterial arabinogalactans^[5] and for lactoferrin.^[8]

AliasesITLN1, HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1

External IDsOMIM: 609873; MGI: 1333831; GeneCards: ITLN1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 1 (human)^[1]

Quick facts ITLN1, Identifiers ...

ITLN1
Identifiers
Aliases	ITLN1, HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1
External IDs	OMIM: 609873; MGI: 1333831; GeneCards: ITLN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WMQ, 4WMY
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 160,876,540 bp[1] End 160,885,180 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 171,345,690 bp[2] End 171,362,862 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura mucosa of ileum pericardium mucosa of sigmoid colon germinal epithelium rectum mucosa of transverse colon jejunal mucosa cardiac muscle tissue of right atrium duodenum Top expressed in crypt of lieberkuhn of small intestine Paneth cell duodenum jejunum intestinal villus ileum Ileal epithelium cervix embryo left colon More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding calcium ion binding oligosaccharide binding metal ion binding identical protein binding Cellular component membrane raft anchored component of membrane brush border membrane receptor complex plasma membrane extracellular exosome membrane extracellular region Biological process positive regulation of glucose import positive regulation of protein phosphorylation response to nematode antimicrobial humoral response protein homotrimerization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 55600 16429 Ensembl ENSG00000179914 ENSMUSG00000038209 UniProt Q8WWA0 O88310 RefSeq (mRNA) NM_017625 NM_010584 RefSeq (protein) NP_060095 NP_034714 Location (UCSC) Chr 1: 160.88 – 160.89 Mb Chr 1: 171.35 – 171.36 Mb PubMed search [3] [4]
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Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.^[9][10]