IU1

IU1 is a drug used in scientific research which acts as a selective inhibitor of the ubiquitin-specific processing protease enzyme USP14.^[1] It is of interest in anti-cancer and antiviral research and also as a potential anti-aging drug. Numerous derivatives of IU1 have been developed with up to 10x the potency of IU1 as USP14 inhibitors,^[2][3] but IU1 remains the most widely used compound in research in this area.^{[4][5][6][7][8][9][10]}

CAS Number

• 314245-33-5

PubChem CID

• 675434

ChEBI

• CHEBI:232499

ChEMBL

• ChEMBL1410015

Quick facts Identifiers, CAS Number ...

IU1

Identifiers
IUPAC name 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
CAS Number	314245-33-5
PubChem CID	675434
ChEBI	CHEBI:232499
ChEMBL	ChEMBL1410015
CompTox Dashboard (EPA)	DTXSID80350196
Chemical and physical data
Formula	C18H21FN2O
Molar mass	300.377 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
InChI InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3 Key:JUWDSDKJBMFLHE-UHFFFAOYSA-N

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