IgG4-related skin disease
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| IgG4-related skin disease | |
|---|---|
| Specialty | Dermatology |
IgG4-related skin disease is the recommended name for skin manifestations in IgG4-related disease (IgG4-RD).[1] Multiple different skin manifestations have been described.
Although a clear understanding of the various skin lesions in IgG4-related disease is a work in progress, skin lesions have been classified into subtypes based on documented cases:[2]
- Angiolymphoid hyperplasia with eosinophilia (or lesions that mimic it)[3] and cutaneous pseudolymphoma
- Cutaneous plasmacytosis[Note 1]
- Eyelid swelling (as part of Mikulicz's disease)
- Psoriasis-like eruptions
- Unspecified maculopapular or erythematous eruptions
- Hypergammaglobulinemic purpura and urticarial vasculitis
- Impaired blood supply to fingers or toes, leading to Raynaud's phenomenon or gangrene
In addition, Wells syndrome has also been reported in a case of IgG4-related disease.[5]