The 6 main ruling families are Iwayi, Ademo, Isherolu, Agagi, Ishoke and Ikoregun.
- Chief Obafemi Awolowo, the national leader of the Unity Party of Nigeria (UPN),
- Professor John Olubi Sodipo, the pioneer vice-chancellor of Ogun State University (now Olabisi Onabanjo University).
- Olofin of Ilisan Remo is the traditional ruler of the kingdom under the Remo confederacy.
- Chief Otun, Osi, Balogun, Iyalode, Apena, Lisa, Odi, Olutun, Odofin, Erelu, Luwajo.
- Know kings includes Oba Onasoga (late; reigned circa 1970s–early 1980s)
A key community leader who advocated for healthcare development, including the 1982 appeal to the Seventh-day Adventist Mission that led to the establishment of Babcock University Teaching Hospital.
- Oba Michael Olaitan Nathaniel Sonuga (Daniyan II) (reigned 2009–present)
Current Olofin, known for promoting community unity and development initiatives like the annual Isanbi Day celebration.