Imidazolylindole From Wikipedia, the free encyclopedia Imidazolylindoles are a group of cyclized tryptamines in which the amine has been cyclized into an imidazole ring. They include AGH-107, AGH-192, AGH-194 and AH-494. These compounds are known to act as selective serotonin 5-HT7 receptor agonists.[1][2][3][4] Chemical structures of selected imidazolylindoles AGH-107 AGH-192 AGH-194 AH-494 See also Cyclized tryptamine References [1]Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ (November 2018). "Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists". MedChemComm. 9 (11): 1882–1890. doi:10.1039/c8md00313k. PMC 6256855. PMID 30568756. [2]Jakubowska K, Hogendorf AS, Gołda S, Jantas D (August 2024). "Neuroprotective and Neurite Outgrowth Stimulating Effects of New Low-Basicity 5-HT7 Receptor Agonists: In Vitro Study in Human Neuroblastoma SH-SY5Y Cells". Neurochem Res. 49 (8): 2179–2196. doi:10.1007/s11064-024-04159-z. PMC 11233329. PMID 38834845. [3]Hogendorf AS, Hogendorf A, Popiołek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ (May 2019). "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". Eur J Med Chem. 170: 261–275. doi:10.1016/j.ejmech.2019.03.017. PMID 30904783. [4]Pochwat B, Masternak J, Bobula B, Bijata K, Chruścicka-Smaga B, Turek J, Hogendorf A, Walczak M, Smolik M, Worch R, Kusek M, Bojarski AJ, Tokarski K, Szewczyk B, Bijata M (2026). "Chronic 5-HT7R activation drives depressive phenotypes and synaptic dysfunction". Acta Pharmacologica Sinica. doi:10.1038/s41401-025-01722-4. This article about an organic compound is a stub. You can help Wikipedia by adding missing information.vte Related Articles
