Indaziflam

In 1991, the Japanese company Idemitsu Kosan filed a patent to 2-amino 6-fluoroalkyl triazine derivatives as herbicides.^[3] One of these compounds was subsequently given the ISO common name triaziflam but had limited success as a commercial herbicide.^[4][5] Bayer scientists subsequently investigated this area of chemistry and identified indaziflam as having superior properties, which they patented and developed under the code number BCS-AA10717.^[6][7] The compound was first registered for use in the USA in 2010.^[8][9]

Indaziflam is an inhibitor of cellulose biosynthesis. This mechanism of action was theorized to be responsible for indaziflam's effect in 2009^[7] and proven in 2014.^[10] The cellulose biosynthesis inhibitors (CBIs) are identified as Group 29 (Aus: Group O, WSSA: Group L) by the Weed Science Society of America/Herbicide Resistance Action Committee.^[11][12]

As of March 2021^[update] there are no resistant populations known^[13] and none for the broader CBI class (discounting quinclorac).^{[11][14][15][16][17]}

Indaziflam composes all or part of the a.i. of several herbicides from Bayer Environmental Science (now owned by Cinven, aka Envu, per Bayer's and Envu's websites), ^{[18] [19]} including Rejuvra,^[20] the Esplanade^[21] line (sometimes mixed with diquat dibromide and glyphosate isopropylamine),^[22] Marengo,^[23][24] Specticle,^[25][24] and Bayer CropScience (the inventor of the ingredient), like Alion.^[26]

Indaziflam is approved in the United States for hops, Rubus spp., Coffea spp., bushberries, tropical crops, drupes/stone fruit, and tree nuts.^[27] It is used as a preemergent.^[28][27]