Indriline
Stimulant and antidepressant drug
From Wikipedia, the free encyclopedia
Indriline is a central nervous system stimulant with antidepressant activity and application in the treatment of gastric ulcers.
| |
| Clinical data | |
|---|---|
| Other names | Lu 3-083, MJ 1986. |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C19H21N |
| Molar mass | 263.384 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
A patent using this chemical is assigned to:[1] Pharmacology.[2]
Synthesis
The chemical synthesis of indriline has been described:[3][4]
Treatment of 3-phenylindene [1961-97-3] (1) with n-butyl lithium and dimethylamino-2-choroethane gave indriline as well as some inactive isomer. Based on neighboring group participation (NGP), the reaction intermediate is presumably an aziridinium ion[4]
According to Molbase the number of routes for preparing the starting 3-phenylindene is rich. For example from dihydrochalcone.[5] A more classical synthesis is also described in a Pyrophendane patent.