Insanitarium

Jack (Jesse Metcalfe) goes undercover as a new patient in order to save his sister, Lily (Kiele Sanchez), who has been involuntarily institutionalized for reasons unknown. The siblings soon find that a mad doctor at the asylum, Dr. Gianetti (Peter Stormare), has been testing an experimental compound, orphium, on the patients that seems to be turning them into flesh-eating zombies; Loomis (Kurt Caceres), another patient, spreads the infection. The two siblings band together with a terminally paranoid man, Dave (Kevin Sussman), and a helpful nurse, Nancy (Olivia Munn), in the hopes of finding a way out of the asylum. They are attacked by most of the prisoners and staff, who kill Nancy; while on the 4th floor, they encounter Gianetti, who gives Dave an icepick lobotomy, incapacitating him; he attempts to get Jack too, but ends up being infected by Loomis. At the end of the film, the two siblings flag down a pair of officers (Mark Kelly & Sharon Schaffer) in their police car and ask for their help, but when the officers arrive at the asylum to investigate, they accidentally let the patients escape into the outside world. It ends with a panning shot, revealing the city below the asylum's hillside location.

The secondary plot focuses on the affair between Charles (Evan Parke) and Heather (Lisa Arturo).