Iso (American football)
From Wikipedia, the free encyclopedia

An iso, short for isolation and also known as a halfback lead, is a simple run play in American football which is designed to isolate the fullback on a lead block with a linebacker, giving the halfback an easy 5 yards.[1] Meanwhile, the other linebackers are blocked with zone blocks from the offensive line. It is one of the most commonly run concepts in football, and is useful in most situations.