Isobuscaline

Isobuscaline (IB), also known as 4-isobutoxy-3,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.^[1][2] It is the analogue and skeletal isomer of buscaline in which there is an isobutoxy group instead of a butoxy group at the 4 position.^[1][2] The drug's dose range is 60 to 100 mg orally and its duration is 8 to 14 hours.^[1] Its effects included little in the way of psychedelic visuals, no enhanced fantasy, and body load.^[1] The chemical synthesis of isobuscaline has been described.^[2] The drug was described in the scientific literature by Daniel Trachsel in 2002.^[2] It is not a controlled substance in Canada as of 2025.^[3]

Other names4-Isobutoxy-3,5-dimethoxyphenethylamine; 3,5-Dimethoxy-4-isobutoxyphenethylamine

Routes of
administrationOral^[1]

Drug classSerotonergic psychedelic; Hallucinogen

ATC code

• None

Quick facts Clinical data, Other names ...

Isobuscaline

Clinical data
Other names	4-Isobutoxy-3,5-dimethoxyphenethylamine; 3,5-Dimethoxy-4-isobutoxyphenethylamine
Routes of administration	Oral[1]
Drug class	Serotonergic psychedelic; Hallucinogen
ATC code	None
Pharmacokinetic data
Duration of action	8–14 hours[1]
Identifiers
IUPAC name 2-[3,5-dimethoxy-4-(2-methylpropoxy)phenyl]ethanamine
CAS Number	501700-05-6
PubChem CID	57478628
ChemSpider	38643131
Chemical and physical data
Formula	C14H23NO3
Molar mass	253.342 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)COC1=C(C=C(C=C1OC)CCN)OC
InChI InChI=1S/C14H23NO3/c1-10(2)9-18-14-12(16-3)7-11(5-6-15)8-13(14)17-4/h7-8,10H,5-6,9,15H2,1-4H3 Key:KNAFUDQAABKKDG-UHFFFAOYSA-N

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