Isoflavonoid synthase
Class of enzymes
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2-hydroxyisoflavanone synthase (EC 1.14.14.87, CYT93C, IFS, isoflavonoid synthase) is an enzyme with systematic name liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration).[1][2] It catalyses a rearrangement reaction which converts flavonoids into isoflavones, for example:
| Isoflavonoid synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.87 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The product 2,4',7-trihydroxyisoflavanone is unstable and loses water, either spontaneously or by the action of 2-hydroxyisoflavanone dehydratase, giving daidzein.[3]
The enzyme can also act on naringenin, leading to the isoflavone genistein.{[4]
Isoflavonoid synthase is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate (NADPH).[5]
